Canine Hemangiosarcoma MicroRNA Differential Expression Analysis in FFPE Tissues

Laura Machado Ribas published this dataset on figshare in March 2026. It contains results from a differential expression analysis of microRNAs in canine visceral hemangiosarcoma, comparing 24 tumor samples to 12 non-neoplastic controls. The data includes validated miRNA signatures and pathway enrichment results for oncogenic signaling pathways.

Use Cases

• Identifying potential diagnostic miRNA biomarkers for canine visceral hemangiosarcoma based on the 13 validated differentially expressed miRNAs.
• Analyzing oncogenic pathway involvement (e.g., PI3K-Akt, MAPK) based on the pathway enrichment results mentioned in the description.
• Comparing miRNA expression profiles between splenic and cardiac tumor subtypes based on the reported 18 shared miRNAs.
• Evaluating the utility of formalin-fixed, paraffin-embedded (FFPE) tissues for biomarker discovery as described in the study.

Strengths

• Includes validated results for 13 differentially expressed miRNAs in each tissue type.
• Pathway enrichment analysis reveals significant involvement in specific oncogenic signaling pathways.
• Data is derived from 24 tumor samples and 12 controls, providing a comparative basis.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small at 11.5 KB, indicating limited scope.
• Data may reflect the specific biological and methodological bias inherent to the original study on figshare.

Provenance

Source

figshare, author Laura Machado Ribas.

Collection Method

Analysis of formalin-fixed, paraffin-embedded (FFPE) tissues using small RNA sequencing and quantitative PCR.

Time Range

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Freshness

Last updated 2026-03-17 14:39:59; freshness should be verified.

Geography

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