Table 4_Molecular epidemiology and genomic evolution mechanism of carbapenemase-resistant Enterobacter cloacae complex in Northeast China from July 2019 to March 2025.xlsx

From July 2019 to March 2025, this dataset contains genomic and phenotypic data on 123 clinical isolates of carbapenem-resistant Enterobacter cloacae complex (CRECC) from Northeast China. The study characterizes species, resistance genes, sequence types, and plasmid vectors using whole-genome sequencing. It was authored by Ze Li to inform infection control strategies.

Use Cases

• Analyze the distribution of resistance genes like bla_NDM-5 and bla_NDM-1 across the 123 CRECC isolates to identify dominant resistance mechanisms.
• Investigate the clonal expansion of dominant sequence types, such as ST171 and ST1120, using genomic data to understand transmission dynamics.
• Study the role of the IncX3 plasmid as a vector for bla_NDM gene dissemination, supported by conjugation experiment results with a 28.0% transfer success rate.
• Examine the association between species classification (e.g., Enterobacter hormaechei subspecies xiangfangensis) and antimicrobial susceptibility profiles like meropenem MIC90.

Strengths

• Data is derived from 123 clinical isolates subjected to whole-genome sequencing, providing a detailed molecular profile.
• Clear temporal coverage from July 2019 to March 2025, offering a multi-year view of genomic evolution.
• Includes phenotypic confirmation of carbapenemase production and plasmid conjugation experiments, linking genotype to transferable phenotype.
• Published under a permissive CC BY 4.0 license, facilitating reuse and analysis.

Limitations

• The dataset is small in scale at 14.5 KB, containing data on only 123 isolates, which may limit statistical power for some analyses.
• Geographic scope is limited to Northeast China, so findings may not be generalizable to other regions.
• Specific column names and data structure are not provided in the input, which may complicate initial data exploration.

Provenance

Source

Ze Li, via the figshare platform.

Collection Method

Whole-genome sequencing, antimicrobial susceptibility testing, plasmid analysis, and conjugation experiments on clinical isolates.

Time Range

July 2019 to March 2025.

Freshness

Last updated on March 23, 2026, indicating recent availability.

Geography

Northeast China.