Neuro-Ophthalmic Complications of Tuberculosis: Incidence and Risk Factors

A systematic review and meta-analysis of 22 studies (N=260,430) evaluates neuro-ophthalmic complications of tuberculosis and its treatment. The work, authored by Ahmed A. Alessa and published on figshare in May 2026, reports pooled incidence rates, risk factors, and prognostic biomarkers. It follows PRISMA 2020 guidelines and includes data from PubMed, Scopus, Embase, Web of Science, Cochrane Library, and Google Scholar.

Use Cases

• Estimate incidence of ethambutol optic neuropathy based on the reported pooled incidence of 1.54%.
• Identify risk factors for neuro-ophthalmic complications based on reported odds ratios for renal impairment and hypertension.
• Compare diagnostic efficacy of biomarkers based on the reported Hedges' g difference between visual evoked potential and optical coherence tomography.
• Analyze visual recovery outcomes based on the reported 52.4% recovery rate and associated factors like age and treatment timing.

Strengths

• Includes 22 studies with a total sample size of 260,430 participants.
• Reports specific statistical results, including pooled incidence (1.54%), odds ratios (e.g., 3.73 for renal impairment), and comparative metrics (Hedges' g difference: 0.686).
• Follows a standardized methodology (PRISMA 2020) and is registered with PROSPERO (CRD420251141453).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a 17.3 KB DOCX file, suggesting limited scope and likely containing summary tables rather than raw study data.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis following PRISMA 2020 guidelines, searching multiple databases up to September 2025.

Time Range

Studies included up to September 2025.

Freshness

Last updated 2026-05-29 04:44:46; freshness should be verified.