Niraparib Ferroptosis Study Data: BRCA Wild-Type Ovarian Cancer

A research dataset from a study investigating the antitumor mechanism of niraparib in BRCA wild-type ovarian cancer. The data likely contains results from assays measuring 6mA modification levels, TM4SF1 expression, and ferroptosis markers like Fe2+ and lipid ROS. The dataset was authored by Po-Wu Liu and last updated on June 1, 2026.

Use Cases

• Analyze the relationship between ALKBH1 expression and 6mA modification levels based on the described experimental assays.
• Investigate correlations between TM4SF1 knockdown and tumor cell proliferation/invasion metrics described in the study.
• Model the induction of ferroptosis based on Fe2+ accumulation and lipid ROS production data referenced in the results.

Strengths

• Dataset is licensed under CC-BY-4.0, permitting open sharing and adaptation.
• The underlying research employs multiple validation methods including in vivo xenograft models and in vitro assays.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 17.7 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Data likely generated from laboratory experiments including dot blot, ELISA, 6mA-IP-seq, RT-qPCR, Western blot, CCK-8 assay, colony formation, wound healing, Transwell assays, and xenograft models.

Freshness

Last updated 2026-06-01 07:43:58; freshness should be verified.