Peripheral CD4+ Naïve T Cell and MMP1 Signatures in Acute Gouty Arthritis

Mass cytometry and single-cell RNA-seq data from a study investigating immune remodeling in acute gouty arthritis. The dataset includes CyTOF analysis of PBMC samples from 56 patients and 9 healthy controls, plasma proteomic data from 104 individuals, and results from bidirectional Mendelian randomization analysis. Author Peng Zhang uploaded the data to figshare under a CC-BY-4.0 license in May 2026.

Use Cases

• Identify immune cell phenotypes associated with gout risk based on Mendelian randomization results.
• Analyze transcriptional features of CD4+ naïve T cells during acute flares using single-cell RNA-seq data.
• Validate plasma protein biomarkers like MMP1 and S100A12 for recurrence risk stratification.
• Investigate cell-cell communication pathways such as MIF–CXCR2 and ANXA1–FPR1 signaling in gout inflammation.

Strengths

• Includes multi-modal data from CyTOF, single-cell RNA-seq, plasma proteomics, and Mendelian randomization.
• Clinical cohorts are defined with specific sample sizes: CyTOF (n=56 patients, n=9 controls) and proteomics (n=104 total).
• Data is associated with a detailed methodological description including bidirectional MR and prospective clinical follow-up.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (14.0 KB), suggesting it contains summary or processed results rather than raw experimental data.

Provenance

Source

Peng Zhang via figshare.

Collection Method

Integrated analysis using CyTOF immune profiling, single-cell RNA-seq re-analysis, plasma proteomics (Olink platform), and Mendelian randomization from public GWAS.

Freshness

Last updated 2026-05-26 06:03:51; freshness should be verified.

Geography

Study cohorts include individuals of European ancestry (for GWAS) and Chinese cohorts (for CyTOF and proteomics).