Table 4_Placental transcriptome profiling in congenital Chagas disease: gene networks asso

Transcriptomic analysis of placental tissues from deliveries of congenitally infected, exposed but uninfected, and unexposed/uninfected newborns. The dataset, last updated in March 2026, was created by Sofia Apodaca and shared under a CC-BY-4.0 license. It includes results from differential gene expression, gene set enrichment, and co-expression network analysis to identify factors associated with vertical transmission of Trypanosoma cruzi.

Use Cases

• Identify differentially expressed genes associated with congenital transmission based on comparisons between infected, exposed, and control placental samples.
• Investigate the role of extracellular matrix and cell adhesion pathways in placental barrier function using Gene Ontology enrichment results.
• Analyze cell type-specific transcriptional signatures, such as those from extravillous trophoblasts and syncytiotrophoblasts, in transmitting versus non-transmitting placentas.
• Explore co-expression networks to identify central hub genes like ENPP1 and SLC16A10 implicated in placental signaling and structural integrity.

Strengths

• Dataset is focused on a specific, understudied mechanism of disease transmission (congenital Chagas).
• Analysis includes multiple comparison groups (M+B+, M+B−, M−B−) and multiple analytical techniques (differential expression, GSEA, co-expression networks).
• Specific, novel findings are reported, such as the involvement of the lncRNA ENSG00000304767 and CEMIP.

Limitations

• The dataset is very small at 59.3 KB, suggesting it contains summary results rather than raw sequencing data.
• Row count and column-level documentation are unknown, limiting suitability assessment.
• The data is contained in a DOCX file, which is not a standard format for structured bioinformatics data and may require extraction.

Provenance

Source

Sofia Apodaca, via figshare.

Collection Method

RNA-seq analysis of placental tissues from categorized patient deliveries.

Freshness

Last updated 2026-03-18 06:43:04.