Platelet-Derived Mediators in 245 Hospitalized COVID-19 Patients

Kari Otterdal's dataset contains plasma levels of 8 platelet-derived mediators measured in 245 hospitalized COVID-19 patients. The data includes measurements taken during hospitalization and at three follow-up points up to 12 months later for a subpopulation. The dataset was last updated on March 17, 2026, and is licensed under CC-BY-4.0.

Use Cases

• Predicting ICU admission or respiratory failure risk based on P-selectin levels.
• Modeling 60-day mortality risk based on levels of PF4/CXCL4, ENA-78/CXCL5, and NAP-2/CXCL7.
• Analyzing long-term platelet activation by tracking sCD40L, ENA-78/CXCL7, and VEGF-A levels up to 12 months post-hospitalization.
• Investigating in vitro platelet response to SARS-CoV-2 using mediator release data.

Strengths

• Includes longitudinal data with follow-up measurements at 3, 6, and 12 months for a subpopulation.
• Focuses on 8 specific platelet-derived mediators (e.g., RANTES, P-selectin, VEGF-A) with clear clinical associations.
• Based on a cohort of 245 hospitalized COVID-19 patients.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is very small at 38.5 KB, indicating limited scope.
• Data may reflect temporal and patient population bias inherent to the original study.

Provenance

Source

Kari Otterdal via figshare.

Collection Method

Plasma levels of mediators were measured in hospitalized patients and at follow-up intervals; in vitro experiments with isolated platelets were also conducted.

Time Range

Measurements during hospitalization and at 3, 6, and 12 months post-hospitalization.

Freshness

Last updated 2026-03-17 13:04:48.