Breg-Related Gene Signature for HNSCC Prognosis and Immune Analysis

An eight-gene prognostic signature derived from regulatory B cell-related genes for head and neck squamous cell carcinoma (HNSCC). The signature was developed using data from The Cancer Genome Atlas (TCGA)-HNSCC cohort and validated with additional TCGA and Gene Expression Omnibus (GEO) cohorts. The dataset, authored by Junyan He and last updated in April 2026, is a 21.5 KB document file.

Use Cases

• Predicting patient survival outcomes based on the eight-gene Breg-related signature.
• Analyzing associations between gene signature risk scores and tumor mutation burden (TMB).
• Investigating links between the prognostic signature and immune checkpoint expression.
• Assessing potential drug sensitivity based on the gene signature risk score.

Strengths

• Signature is an eight-gene model validated across multiple cohorts (TCGA and GEO).
• Analysis includes associations with clinicopathological features, immune checkpoints, and tumor mutation burden.
• Dataset is openly licensed under CC-BY-4.0.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is contained in a 21.5 KB DOCX file, suggesting limited raw data scope.

Provenance

Source

The Cancer Genome Atlas (TCGA)-HNSCC and Gene Expression Omnibus (GEO) databases.

Collection Method

Analysis involved consensus clustering, univariate Cox regression, LASSO Cox regression, and multivariate Cox regression.

Time Range

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Freshness

Last updated 2026-04-10 05:58:12; freshness should be verified.

Geography

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