Danggui Sini Granule Gut-Heart Axis Study in Vasospastic CHD Rats

A research document details a multi-omics study on Danggui Sini Granule's cardioprotective effects in a rat model of vasospastic coronary heart disease. The study integrates pharmacodynamic evaluations, 16S rRNA gut microbiota profiling, untargeted serum metabolomics, and network pharmacology analyses. The document was authored by Haipeng Tang and uploaded to figshare in May 2026.

Use Cases

• Analyze gut microbiota modulation in a disease model based on 16S rRNA sequencing results
• Study serum metabolic pathway disturbances based on untargeted metabolomics findings
• Validate predicted molecular targets based on network pharmacology and molecular docking results
• Investigate cardioprotective mechanisms based on integrated pharmacodynamic and multi-omics data

Strengths

• The study employs a multi-omics approach integrating pharmacodynamics, 16S rRNA sequencing, and metabolomics
• Results include specific findings such as modulation of TNF-α and IL-6 inflammatory mediators
• The document is licensed under CC-BY-4.0 for open sharing

Limitations

• The dataset is a 15.6 KB DOCX file, suggesting limited scope and likely containing summary text rather than raw data
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Experimental study using a rat model, multi-omics profiling, and computational analysis

Freshness

Last updated 2026-05-22 04:28:10