RZV Vaccine: Repeated Dose Toxicity and Immunogenicity Studies in SD Rats

17.8 KB of tabular data from a non-clinical safety assessment of a recombinant zoster vaccine formulated with adjuvant BC02. The dataset likely contains results from general health observations, immunotoxicity assays, hematological profiling, and histopathological evaluations in adult Sprague-Dawley rats. It was authored by Qian Yang and published on figshare under a CC-BY-4.0 license.

Use Cases

• Assessing vaccine safety based on general health observations and histopathological evaluations
• Evaluating immunogenicity based on cellular and humoral response assays
• Determining no-observed-adverse-effect levels (NOAEL) based on toxicology data

Strengths

• Data supports a specific NOAEL determination of 1.0 mL per rat
• Results are derived from a systematic toxicology program including multiple assessment methods

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download

Provenance

Source

figshare

Collection Method

Experimental study involving four subcutaneous doses of vaccine administered to rats.

Freshness

Last updated 2026-05-22 05:35:48