Retinoic Acid Transcriptomic Effects on PRRSV-Infected Porcine Macrophages

Transcriptomic profiling data from 2026 investigates the antiviral effects of all-trans retinoic acid (ATRA) against porcine reproductive and respiratory syndrome virus (PRRSV). The dataset contains results from experiments in MARC-145 cells and primary porcine alveolar macrophages (PAMs). It was created by Jintong Guo to elucidate mechanisms of immune modulation and metabolic restoration.

Use Cases

• Analyze transcriptomic profiling data to identify genes upregulated by ATRA treatment in uninfected PAMs.
• Compare gene expression patterns between PRRSV-infected and ATRA-treated PAMs to study inflammation suppression.
• Investigate the relationship between lipid homeostasis pathways and viral infection outcomes using the provided data.

Strengths

• Data originates from a peer-reviewed scientific study on a major swine pathogen, PRRSV.
• Includes transcriptomic results from two distinct cell types: MARC-145 cells and primary porcine alveolar macrophages.
• Dataset is openly available under a CC BY 4.0 license, facilitating reuse.

Limitations

• The dataset is small in scale at 768.9 KB, indicating limited raw data or processed summary results.
• Sample data and column structure are unavailable, complicating direct analysis without the original paper.
• Data is derived from controlled in vitro experiments, which may not directly translate to in vivo conditions.

Provenance

Source

Jintong Guo via figshare.

Collection Method

Generated from transcriptomic profiling of porcine alveolar macrophages under PRRSV infection and ATRA treatment.

Time Range

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Freshness

Last updated in March 2026.

Geography

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