Post-Hoc Analysis of Non-Invasive Vagus Nerve Stimulation for Chronic mTBI with PTSD

A retrospective observational cohort study by Michael Ament, published on figshare in April 2026. This post-hoc subgroup analysis examines the impact of adjunctive non-invasive vagus nerve stimulation (nVNS) on symptom severity in adults with chronic mild traumatic brain injury (mTBI) and comorbid post-traumatic stress disorder (PTSD). Results include baseline and follow-up Neurobehavioral Symptom Inventory (NSI) scores for a PTSD-enriched subgroup.

Use Cases

• Analyze symptom domain improvements (affective, cognitive, somatic, vestibular) based on NSI scores mentioned in the description.
• Model treatment response predictors based on the high-symptom-burden phenotype identified in multivariate analyses.
• Evaluate the proportion of patients achieving clinically meaningful improvement (≥30% symptom reduction) as reported in the results.

Strengths

• Includes specific quantitative results, such as mean NSI score reduction from 2.50 to 2.03 and domain-level improvements with FDR-corrected q-values.
• Clear methodological description of a post-hoc analysis from a retrospective cohort, assessing symptom change over 3–4 months.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (17.9 KB), indicating limited scope, likely a summary table rather than raw patient-level data.

Provenance

Source

Michael Ament via figshare.

Collection Method

Post-hoc subgroup analysis of a previously published retrospective observational cohort.

Time Range

Study period not specified; analysis published in 2026.

Freshness

Last updated 2026-04-13 05:44:22; freshness should be verified.

Geography

Geographic coverage of the patient cohort is not specified.