Systematic Review of S100 Proteins in IgA Vasculitis

54 studies were synthesized in a PRISMA-compliant systematic review investigating S100 proteins in vasculitides. The review, authored by Zofia Podraza and updated in March 2026, focuses on the mechanistic and clinical roles of S100A8/9, S100A12, S100A4, and S100A10. It evaluates their potential as biomarkers for disease activity and prognosis in IgA vasculitis and other systemic vasculitides.

Use Cases

• Analyze the reported evidence on S100A8/9 and S100A12 as markers of neutrophil-driven inflammation and disease activity.
• Compare findings on S100A4 and S100A10 across studies to identify fragmentary or indirect evidence in vasculitis research.
• Synthesize data from the 54 included studies to evaluate the potential of specific S100 proteins as clinical biomarkers for risk stratification in IgA vasculitis.

Strengths

• Synthesizes findings from 54 original human studies on a specific biological pathway.
• Follows a PRISMA-compliant systematic review methodology for structured evidence synthesis.
• Focuses on four specific S100 protein families (S100A8/9, S100A12, S100A4, S100A10) with clear biological relevance.

Limitations

• The dataset is a summary table from a literature review (18.3 KB), not raw experimental or patient-level data.
• Findings for S100A4 and S100A10 are described as fragmentary and lack sufficient IgA vasculitis-specific data.
• Evidence is synthesized narratively; no quantitative meta-analysis or aggregated statistical results are provided.

Provenance

Source

Systematic review of PubMed, Embase, Scopus, and Web of Science.

Collection Method

PRISMA-compliant systematic search and narrative synthesis of original human studies.

Time Range

Literature search covered studies up to November 2025.

Freshness

Literature search conducted up to November 18, 2025; dataset last updated March 25, 2026.

Geography

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