SGLT2 Inhibitor Cancer Risk Meta-Analysis: 28 Trials and 98,297 Participants

A systematic review and meta-analysis document assessing the long-term safety of Sodium-glucose cotransporter 2 (SGLT2) inhibitors concerning cancer risk in specific patient populations. The document includes results from 28 randomized controlled trials involving 98,297 participants, published by author Jing Teng and last updated in May 2026. It reports pooled risk ratios for overall cancer risk and specific cancer types in patients with Type 2 diabetes, heart failure, and chronic kidney disease.

Use Cases

• Conducting a secondary analysis of cancer risk associated with SGLT2 inhibitors based on the reported meta-analysis results.
• Validating safety findings for specific patient subgroups (e.g., heart failure, chronic kidney disease) mentioned in the review.
• Comparing the cancer risk profile of SGLT2 inhibitors to other diabetes medications using the reported risk ratios and confidence intervals.

Strengths

• Analysis is based on 28 randomized controlled trials, a substantial number for a meta-analysis.
• Includes data from 98,297 participants, providing a large sample size for safety evaluation.
• Reports specific risk ratios with 95% confidence intervals for overall and subgroup analyses.

Limitations

• The primary data file is a DOCX document; the underlying tabular data for the meta-analysis is not provided as a separate structured dataset.
• Column-level documentation for any potential supplementary data is absent; field semantics must be inferred from the document text.
• Row count for any underlying data tables is unknown, which may limit suitability assessment for computational analysis.

Provenance

Source

figshare, author Jing Teng.

Collection Method

Systematic review and meta-analysis of studies from PubMed, CENTRAL, Web of Science, and ClinicalTrials.gov up to April 16, 2024.

Time Range

Studies published up to April 16, 2024.

Freshness

Last updated 2026-05-08 05:57:09; freshness should be verified as the date is in the future relative to the current time.