Serum Calcium Dynamics and Hydrocephalus Prediction After Subarachnoid Hemorrhage

An observational cohort study analyzed 302 patients with spontaneous subarachnoid hemorrhage (SAH) to predict delayed hydrocephalus. The research developed a clinical nomogram using serial serum calcium measurements and admission variables, achieving an AUC of 0.898 in external validation. It was authored by Di Wu and published in 2026.

Use Cases

• Predict delayed hydrocephalus risk using serial serum calcium measurements at admission, 72 hours, and 7 days post-ictus.
• Validate the performance of a clinical nomogram incorporating admission serum calcium, hypertension, and Hunt-Hess grade.
• Analyze the association between hypocalcemia at 72 hours (cutoff ≤7.65 mg/dL) and the incidence of delayed hydrocephalus.
• Compare the predictive accuracy of serum calcium dynamics against conventional severity scales using ROC analysis.

Strengths

• Dataset is based on a cohort of 302 patients, providing a substantive sample for analysis.
• Model demonstrated excellent predictive performance with an AUC >0.93 in internal validation and 0.898 externally.
• Study includes serial measurements of serum calcium at three specific time points, enabling dynamic analysis.

Limitations

• The dataset is small in file size (18.1 KB), suggesting it contains summary or model results rather than raw patient-level data.
• Generalizability may be limited as the proposed serum calcium cutoff may vary across different laboratory assays.
• Specific column names and row counts for the underlying patient data are not provided in the input.

Provenance

Source

figshare, authored by Di Wu.

Collection Method

Observational cohort study analyzing serial serum calcium measurements in SAH patients monitored for 90 days.

Time Range

Patient monitoring period spanned 90 days post-ictus.

Freshness

Last updated in March 2026, indicating recent publication.

Geography

External validation was conducted using a cohort from two hospitals; specific locations are unknown.