Single-Cell Transcriptomic Profiling of Halo Nevi and Normal Nevi

Table 4_Single-cell transcriptomic profiling of halo nevi and normal nevi reveals CD8+ T cell activation in melanocytic autoimmunity.xlsx is a 29.6 MB dataset shared by Wenxuan Gao on figshare under a CC-BY-4.0 license, last updated on 2026-05-14. The data provides a single-cell transcriptional atlas comparing halo nevi and normal nevi, identifying ten canonical skin cell types and five melanocyte subclusters.

Use Cases

• Identify activated, interferon-responsive CD8+ T cell infiltration based on the description of halo nevi.
• Compare melanocyte subcluster gene expression, including antigen-presenting molecules and interferon-stimulated genes, as described.
• Analyze upregulated pathways in halo nevi melanocytes, such as oxidative phosphorylation and antigen processing and presentation.
• Investigate shared pathogenic mechanisms with vitiligo based on the comparative analyses mentioned.

Strengths

• Dataset is 29.6 MB, indicating a manageable file size for analysis.
• Data is licensed under CC-BY-4.0, permitting broad reuse with attribution.
• Description details specific biological findings, including ten cell types and five melanocyte subclusters.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Wenxuan Gao

Collection Method

Single-cell RNA sequencing (scRNA-seq) and immunofluorescence staining, as described.

Time Range

null

Freshness

Last updated 2026-05-14 08:46:14; freshness should be verified.

Geography

null