Mouse Dentate Gyrus Gene Expression Patterns After Denervation

Table 4_Spatiotemporal patterns of gene expression changes in the mouse dentate gyrus following entorhinal denervation.xlsx contains transcriptomic data from a study of brain injury response. Jessica Schlaudraff published the dataset on figshare under a CC-BY-4.0 license, last updated on 2026-05-19. The data likely contains gene expression levels measured in the outer molecular layer and granule cell layer at 1, 3, 7, 14, and 28 days post-lesion.

Use Cases

• Analyze temporal dynamics of glial activation based on time-series measurements of astrogliosis and microgliosis.
• Investigate compensatory synaptic remodeling based on expression changes in genes like Nrp1, Sema3e, and synaptic adhesion mediators.
• Model metabolic adaptation after injury based on late downregulations of respiratory factors and upregulation of ribosomal translation.
• Study layer-specific transcriptional responses based on comparisons between the outer molecular layer and granule cell layer.

Strengths

• Data is structured across five specific time points (1, 3, 7, 14, and 28 days post-lesion), enabling longitudinal analysis.
• Description provides specific gene expression changes, such as Sema3e reduced to 60% in OML and Nrp1 induced 3-fold in OML and 7-fold in GCL.
• Dataset isolates tissue from two distinct brain layers (outer molecular layer and granule cell layer) using laser microdissection.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect experimental bias inherent to the specific mouse model and lesion technique used.

Provenance

Source

Jessica Schlaudraff

Collection Method

Whole-genome expression analysis performed on laser-microdissected tissue from mouse dentate gyrus after perforant path transection.

Time Range

Measurements taken at 1, 3, 7, 14, and 28 days post-lesion.

Freshness

Last updated 2026-05-19 05:40:47; freshness should be verified.