Carbapenem-Resistant Enterobacteriaceae in Pediatric Patients from Eastern China

Yihan Zheng's dataset contains 281 non-duplicated clinical isolates of Carbapenem-resistant Enterobacteriaceae (CRE) from children in Suzhou, eastern China. The data includes strain identification, antimicrobial susceptibility profiles, and prevalence of carbapenemase, ESBL, AmpC, and hypervirulence-associated genes. The dataset was last updated on 2026-05-28.

Use Cases

• Analyzing the distribution of carbapenemase gene types (e.g., blaOXA-232, blaKPC-2) among CRE strains.
• Investigating correlations between specific bacterial species (e.g., Klebsiella pneumoniae, Escherichia coli) and antimicrobial resistance profiles.
• Studying the co-occurrence of hypervirulence genes (e.g., iucA, rmpA) and carbapenem resistance in Klebsiella pneumoniae isolates.
• Assessing the prevalence of extended-spectrum β-lactamase (ESBL) genes like blaTEM-1 and blaCTX-M-14 in pediatric CRE infections.

Strengths

• Contains 281 non-duplicated clinical isolates, providing a defined sample size.
• Reports specific prevalence percentages for key resistance genes (e.g., blaOXA-232 at 38.08%).
• Identifies 22 (14.01%) strains as carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CR-HVKP).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to a single region in eastern China.

Provenance

Source

Yihan Zheng via figshare.

Collection Method

Clinical strains were isolated, identified via mass spectrometry, and analyzed for antimicrobial susceptibility and resistance/hypervirulence genes via PCR and sequencing.

Freshness

Last updated 2026-05-28 05:58:22; freshness should be verified.

Geography

Suzhou, eastern China.