Astrocyte Metabolic Model Fluxes for Alzheimer's Disease Progression

A 122.7 KB Excel file from figshare, published under CC-BY-4.0 by Andrea Angarita-Rodríguez and last updated in June 2026. It contains results from a study integrating transcriptomic data from hippocampal CA1 tissue with genome-scale metabolic modeling to analyze astrocyte-specific changes across control, early MCI, advanced MCI, and Alzheimer's disease stages.

Use Cases

• Analyzing stage-dependent metabolic flux changes in astrocytes based on the inferred transcriptional profiles.
• Investigating metabolic flexibility in pathways like glutamate-glutamine cycling and glutathione metabolism across disease stages.
• Validating predictions of astrocyte metabolic reprogramming, such as the reduction in a biomass-derived maintenance proxy.
• Comparing condition-specific metabolic model outputs for control, early MCI, advanced MCI, and AD states.

Strengths

• Data is derived from a published transcriptomic dataset (GSE28146) and integrated with a curated human astrocyte genome-scale metabolic model.
• Analysis includes multiple validation steps, including correlation with external reference signatures and comparison with an independent single-nucleus RNA-seq dataset.
• The dataset is small (122.7 KB), facilitating quick download and initial inspection.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download to understand the data structure.
• The dataset's scope is limited to a specific brain region (hippocampal CA1) and four clinical conditions, which may not generalize to other areas or disease models.
• Column-level documentation is absent; field semantics must be inferred from the accompanying study description.

Provenance

Source

Transcriptomic profiles from hippocampal CA1 tissue (GSE28146).

Collection Method

Integrated transcriptomic analysis and genome-scale metabolic modeling using flux balance analysis (FBA) and flux variability analysis (FVA).

Freshness

Last updated 2026-06-02 05:45:33; freshness should be verified.