Interventions That Decrease Next-Generation Epigenetic Aging Clocks in Humans

41 human studies catalog the effects of diverse interventions on next-generation epigenetic aging clocks. The dataset, compiled via systematic searches, lists interventions like exercise, plant-rich diets, and specific pharmaceuticals that can decrease epigenetic age, while noting others with no effect or that accelerate aging. Adiv A. Johnson published this summary on figshare in May 2026.

Use Cases

• Comparing the efficacy of different interventions on epigenetic age based on reported effect sizes.
• Identifying promising lifestyle or pharmaceutical candidates for longevity studies based on the compiled list of effective interventions.
• Analyzing the relative responsiveness of different next-generation epigenetic clocks to interventions.
• Screening for interventions that showed no detectable effect or accelerated epigenetic aging for further investigation.

Strengths

• Compiles results from 41 identified human studies, providing a consolidated view.
• Focuses on next-generation epigenetic clocks, which are described as more strongly associated with mortality risk than first-generation models.
• Explicitly lists specific interventions like semaglutide and pitavastatin that showed effects.

Limitations

• Row count and specific column-level documentation are unknown, requiring manual inspection after download.
• The dataset is very small at 17.5 KB, indicating it is likely a summary table rather than raw study data.
• Freshness should be verified as the last update timestamp is in the future (2026-05-28).

Provenance

Source

figshare

Collection Method

Compiled via a series of systematic searches of human studies.

Freshness

Last updated 2026-05-28 22:03:23; freshness should be verified.