Sea Urchin Immune Cell Transcriptional Response to UVB-Induced DNA Damage

Transcriptional data from purple sea urchin immune cells exposed to UVB radiation. The dataset likely contains gene expression profiles from single-cell RNA sequencing, generated by Riss M. Kell and published on figshare in March 2026. It captures the activation of DNA damage response, autophagy, ubiquitin signaling, and innate immune pathways.

Use Cases

• Analyze transcriptional activation of DNA damage response genes based on gene expression profiles.
• Compare innate immune pathway induction between cell types based on single-cell RNA sequencing results.
• Investigate crosstalk between autophagy and immune signaling based on pathway activation data.
• Study evolutionary origins of damage recognition systems based on responses in a basal deuterostome.

Strengths

• Data is from a long-lived, cancer-resistant model organism (Strongylocentrotus purpuratus).
• Includes functional assay and western blot validation of transcriptional findings.
• Generated using single-cell RNA sequencing, providing cell-type-specific resolution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (4.2 MB), potentially indicating limited scope or summary-level data.

Provenance

Source

figshare

Collection Method

Single-cell RNA sequencing and functional assays on sea urchin coelomocytes.

Freshness

Last updated 2026-03-19 05:18:34