Plasma Exosomal Protein Profiles for Intrahepatic Cholestasis of Pregnancy

Yuxuan Jiang's proteomics dataset contains quantitative protein profiles from plasma exosomes of 35 pregnant women, including 10 with moderate intrahepatic cholestasis, 10 with severe cases, and 15 healthy controls. SWATH proteomics identified 109 and 46 differentially expressed proteins in total and placenta-derived exosomes, respectively. The data was published on figshare in April 2026 under a CC-BY-4.0 license.

Use Cases

• Identify diagnostic biomarkers for intrahepatic cholestasis of pregnancy based on differentially expressed proteins.
• Analyze protein pathways involved in complement activation and blood coagulation in ICP.
• Validate hub protein candidates like HRG, VWF, and PIGR using proteomic screening data.
• Compare protein expression profiles between total exosomes and placenta-derived exosomes.
• Investigate the fetal stress response hypothesis in ICP pathogenesis using proteomic evidence.

Strengths

• Includes data from 35 patient samples, providing a clinical cohort for comparison.
• SWATH proteomics identified 109 and 46 differentially expressed proteins, offering a quantitative basis.
• Hub proteins HRG, VWF, and PIGR were verified by Western blotting, adding validation.
• Data is openly licensed under CC-BY-4.0, facilitating reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is 22.7 KB, indicating a very limited scope of data.

Provenance

Source

Yuxuan Jiang

Collection Method

Quantitative proteomic profiling using SWATH proteomics on plasma exosomes.

Freshness

Last updated 2026-04-10 06:00:47; freshness should be verified.