ANCA-Associated Vasculitis and Cardiovascular Risk in a Propensity-Matched US Cohort

20,422 patients with granulomatosis with polyangiitis and 5,907 with microscopic polyangiitis were compared to matched controls in a retrospective cohort study using US electronic health records. The study, authored by Sebastian Klapa and last updated in April 2026, calculated hazard ratios for mortality and cardiovascular events. Results indicate an increased risk of death and cardiovascular morbidity in patients with ANCA-associated vasculitis.

Use Cases

• Estimating hazard ratios for mortality based on diagnostic codes for GPA and MPA.
• Comparing cardiovascular event risk between vasculitis patients and matched controls.
• Analyzing the association between ANCA-associated vasculitis and thromboembolic events like deep vein thrombosis and pulmonary embolism.
• Investigating differences in major adverse cardiovascular event risk between GPA and MPA patient subgroups.

Strengths

• Large cohort size with over 26,000 total vasculitis patients identified.
• Used propensity score matching for demographic variables and comorbidity to optimize comparability.
• Results include specific hazard ratios for multiple cardiovascular outcomes, such as MACE and thromboembolic events.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 27.0 KB, suggesting it may contain summary results rather than raw patient-level data.

Provenance

Source

Data sourced from the US-based TriNetX network electronic health records database.

Collection Method

Retrospective cohort study using diagnostic codes and propensity score matching.

Time Range

null

Freshness

Last updated 2026-04-15 05:45:59; freshness should be verified.

Geography

United States