Table 5_Association between circulating biomarkers of one-carbon metabolism and glymphatic

210 participants, including individuals with normal cognition, mild cognitive impairment, and dementia due to Alzheimer's disease, were enrolled in this study. Yali Chen published the data on figshare in May 2026, investigating links between serum folate, vitamin B12, homocysteine, and a neuroimaging index of glymphatic function. The results show significant associations between these biomarkers, glymphatic function, and domain-specific cognitive performance.

Use Cases

• Correlating circulating folate levels with neuroimaging-based glymphatic function indices.
• Investigating sex-specific differences in biomarker levels across cognitive decline stages.
• Modeling combined risk from metabolic and glymphatic dysfunction on memory and processing speed scores.
• Analyzing associations between homocysteine levels and cognitive domain performance in Alzheimer's patients.

Strengths

• Includes data from 210 participants across three diagnostic groups.
• Measures multiple biomarkers (serum folate, vitamin B12, homocysteine) and a neuroimaging index (DTI-ALPS).
• Reports statistically significant correlations (e.g., folate and DTI-ALPS index, r=0.212).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 29.1 KB file size suggests a very limited scope, likely containing summary statistics rather than raw participant data.

Provenance

Source

figshare

Collection Method

Clinical study involving biomarker measurement, neuroimaging, and neuropsychological assessment.

Freshness

Last updated 2026-05-11 04:29:30; freshness should be verified.