aMAP Score Association with Mortality in MASLD/MetALD/ALD Patients: NHANES Cohort Study

A cohort study from 1999 to 2018 using National Health and Nutrition Examination Survey (NHANES) data, with mortality follow-up through 2019, examines the association between the aMAP risk score and mortality in patients with steatotic liver disease. The study includes 32,654 participants and was authored by Peng-yang Li. An independent hospital-based Southern Chinese cohort of 642 participants was used for external validation.

Use Cases

• Validate the aMAP score as a non-invasive mortality predictor based on its association with all-cause, cardiovascular, and cancer mortality.
• Assess risk stratification for high-risk individuals within steatotic liver disease subclassifications based on the described score thresholds.
• Investigate non-linear relationships between risk scores and mortality outcomes using methods like restricted cubic spline analysis mentioned in the description.
• Perform external validation of biomarker associations using independent cohorts, as demonstrated with the Southern Chinese cohort.

Strengths

• Includes 32,654 participants from a nationally representative survey (NHANES).
• Covers a long time range with data from 1999 to 2018 and mortality follow-up through 2019.
• Uses an independent external validation cohort of 642 participants.
• Analyzes multiple mortality outcomes: all-cause, cardiovascular, and cancer.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the primary dataset is unknown, which may limit suitability assessment.
• The dataset is very small (22.6 KB), suggesting it may contain summary or analytical results rather than raw patient-level data.

Provenance

Source

National Health and Nutrition Examination Survey (NHANES) and an independent hospital-based Southern Chinese cohort.

Collection Method

Cohort study using survey data and clinical records.

Time Range

1999 to 2018 (primary data), with mortality follow-up through December 31, 2019.

Freshness

Last updated 2026-04-24 13:49:21; freshness should be verified.

Geography

United States (NHANES) and Southern China (validation cohort).