Table 5_Combined single-cell transcriptome and Mendelian randomization to identify and val

Table 5_Combined single-cell transcriptome and Mendelian randomization to identify and validate prognostic genes associated with endoplasmic reticulum stress and butyrate metabolism in lung adenocarcinoma.xlsx is a 12.6 KB dataset by Jiaxin Li, last updated March 25, 2026. It contains results from an integrated bioinformatics study that identified seven prognostic genes for lung adenocarcinoma. The findings were validated through RT-qPCR assays on non-small cell lung cancer cell lines.

Use Cases

• Building a prognostic risk model for lung adenocarcinoma based on the seven identified genes (VDAC1, TXNRD1, GDF15, TRIB3, LPL, KCNQ1, PKP2).
• Analyzing immune microenvironment composition based on the 13 differentially abundant immune cell types mentioned.
• Investigating pathway enrichment in high- and low-risk patient groups based on described pathways like olfactory transduction and ribosome cascades.
• Validating gene expression patterns in macrophage differentiation based on the single-cell analysis findings for VDAC1, TXNRD1, and LPL.

Strengths

• Identifies seven specific prognostic genes (VDAC1, TXNRD1, GDF15, TRIB3, LPL, KCNQ1, PKP2) with expression validated by RT-qPCR.
• Risk model and nomogram demonstrated predictive accuracy for 1-, 3-, and 5-year survival outcomes.
• Analysis includes results from single-cell transcriptomics, Mendelian randomization, and immune profiling of 13 cell types.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small (12.6 KB), suggesting it contains summary results rather than raw experimental data.
• Data may reflect bias inherent to the specific public datasets and analytical methods used in the source study.

Provenance

Source

Jiaxin Li via figshare.

Collection Method

Integrated analysis of public datasets using weighted gene co-expression network analysis, differential expression analysis, and Mendelian randomization.

Freshness

Last updated 2026-03-25 22:03:05.