Alveolar Macrophage Senescence-Like State Induced by Continuous Antiretroviral Therapy

Vinicius M. Fava published a dataset on figshare in April 2026 analyzing the long-term effects of antiretroviral therapy (ART) on alveolar macrophages. The data likely contains results from a systems immunology approach evaluating transcriptomic and epigenetic changes linked to ART duration. The findings suggest ART induces a progressive senescence-like pro-inflammatory state in these immune cells.

Use Cases

• Modeling the relationship between ART duration and pro-inflammatory gene expression based on the described progressive changes.
• Analyzing coordinated gene regulatory networks in alveolar macrophages based on the single nucleus RNA-seq data mentioned.
• Investigating impaired interferon signaling responses to viral challenges like SARS-CoV-2 based on the described secondary ART effect.

Strengths

• Dataset is published under a permissive CC-BY-4.0 license.
• Description details a specific biological mechanism linking ART duration to cellular senescence.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (101.6 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Systems immunology approach, likely involving single nucleus RNA sequencing and epigenetic analysis.

Freshness

Last updated 2026-04-22 05:49:11; freshness should be verified.