DNER Drives Glycolytic Reprogramming in Renal Cell Carcinoma

A research document from figshare, authored by Anrui Li and last updated on 2026-05-22, describes a study on the role of the DNER gene in clear cell renal cell carcinoma (ccRCC). The study integrates bioinformatic analyses with experimental validation to investigate DNER's function in metabolic reprogramming and immune microenvironment remodeling. The file is 36.6 KB and is shared under a CC-BY-4.0 license.

Use Cases

• Study the link between DNER gene expression and metabolic pathway activity in ccRCC based on the described bioinformatic screening.
• Investigate the mechanistic role of the JAK2/STAT3 signaling axis in tumor progression based on the described functional and mechanistic assays.
• Explore potential connections between tumor cell glycolysis and macrophage polarization based on the described signaling cascade.
• Assess DNER as a potential biomarker for sensitivity to PARP inhibitors like Olaparib based on the preliminary evidence mentioned.

Strengths

• The study description integrates multiple methodological approaches, including bioinformatics, in vitro, and in vivo validation.
• The research identifies a specific molecular mechanism linking DNER to the JAK2/STAT3 pathway and glycolytic enzymes LDHA and PKM.
• The dataset is openly shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The primary data file is a 36.6 KB DOCX document, suggesting it contains a manuscript or summary rather than a raw, structured dataset suitable for direct computational analysis.
• Row and column counts are unknown, and no sample data is provided, making it impossible to assess the scale or structure of any underlying data.
• The description metadata is limited to the study's narrative; actual data quality and availability require manual inspection after download.

Provenance

Source

figshare, author Anrui Li.

Collection Method

Integrated bioinformatic analysis and experimental validation (in vitro and in vivo functional assays, mechanistic studies).

Freshness

Last updated 2026-05-22 06:09:52; freshness should be verified.