Meta-Analysis of Astragalus mongholicus Bunge for Wound Healing in Animal Models

Jun Zhang's systematic review and meta-analysis, registered in PROSPERO (CRD420250641262), synthesizes evidence from 21 preclinical animal studies involving 559 animals. The analysis, last updated in April 2026, evaluates the efficacy and safety of the traditional Chinese botanical drug Astragalus mongholicus Bunge for wound healing. The document reports pooled effect sizes for outcomes like wound contraction percentage, angiogenesis, and collagen deposition.

Use Cases

• Assessing the pooled therapeutic effect of Astragalus mongholicus Bunge on wound contraction percentage based on the reported standardized mean difference.
• Evaluating the impact on biological processes like angiogenesis and collagen deposition based on the described positive effects.
• Informing the design of future preclinical and clinical trials based on the systematic review's conclusions and identified research gaps.

Strengths

• Includes data from 21 studies across 559 animals, providing a quantitative synthesis of evidence.
• Employs a systematic review methodology with a predefined protocol registered in PROSPERO (CRD420250641262).
• Reports specific pooled effect metrics, such as a standardized mean difference of 4.18 for wound contraction.

Limitations

• The dataset is a 231.8 KB DOCX file containing a review article; the underlying raw study data is not directly accessible.
• Row count and column-level documentation for any underlying data are unknown, limiting suitability assessment for direct analysis.
• The findings are specific to preclinical animal models; direct applicability to human clinical contexts is not established.

Provenance

Source

Jun Zhang via figshare.

Collection Method

Systematic search of seven databases for randomized controlled animal studies, followed by meta-analysis using R software.

Freshness

Last updated 2026-04-17 05:08:53.