Table 5_Dose-dependent protective effects of Tripterygium wilfordii glycosides on joint an

Shangwen Qi published experimental data on figshare in April 2026. The dataset contains results from a study on collagen-induced arthritis in Wistar rats, assessing the effects of Tripterygium wilfordii glycosides (TWG) at three doses. It includes histopathological scores, cytokine expression levels, and 16S rRNA sequencing results for gut microbiota analysis.

Use Cases

• Analyzing dose-response relationships for drug efficacy based on three administered dose levels (9, 45, 90 mg/kg).
• Investigating correlations between gut microbiota composition and joint/lung pathology scores mentioned in the description.
• Modeling anti-inflammatory effects based on IL-6 and TNF-α mRNA expression data from joint and lung tissues.
• Studying microbial functional shifts predicted by PICRUSt2 for short-chain fatty acid pathways and xenobiotic degradation.

Strengths

• Includes data from six distinct experimental groups (normal control, model, three dose groups, prednisolone control).
• Combines multiple data modalities: histopathology scores, cytokine mRNA expression, protein expression (Western blot), and 16S rRNA sequencing.
• Data is associated with a specific, detailed experimental protocol from day 15 to day 43 post-induction.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (14.9 KB), indicating limited scope, likely containing summary results rather than raw sequencing reads.

Provenance

Source

Shangwen Qi via figshare.

Collection Method

Experimental data from a controlled animal study using collagen-induced arthritis (CIA) in Wistar rats, with treatments administered by oral gavage.

Time Range

The experiment was conducted over 43 days, with treatments from day 15 to day 42.

Freshness

Last updated 2026-04-23 05:27:26; freshness should be verified.