Multi-Omics Analysis of Daifu Decoction Effects on Ulcerative Colitis in Mice

54.8 KB Excel file contains multi-omics data from a study investigating the molecular mechanisms of Daifu decoction in treating ulcerative colitis. The dataset includes results from transcriptomics, metabolomics, and 16S rRNA sequencing of a DSS-induced mouse model. Author Yangyang Zhao published the data under a CC BY 4.0 license in March 2026.

Use Cases

• Analyze transcriptomics data to identify gene expression changes related to the PKCγ/ERK/NF-κB pathway in treated mice.
• Correlate 16S rRNA sequencing results with metabolomics profiles to study gut microbiota shifts and their association with colitis improvement.
• Validate molecular docking and dynamics simulation findings by examining the binding affinity data for DFD components with the PRKCG target.
• Compare ELISA, qPCR, and immunofluorescence data across three DFD dosage groups (1.6, 3.2, 6.4 g/(kg·d)) to assess dose-response relationships.

Strengths

• Data integrates multiple experimental modalities: transcriptomics, metabolomics, 16S rRNA sequencing, and molecular docking.
• Study includes validation through molecular dynamics simulations, qPCR, western blotting, and immunohistochemistry.
• Dataset is openly shared under a permissive CC BY 4.0 license, facilitating reuse.

Limitations

• The dataset is very small at 54.8 KB, indicating limited scope and likely a summary of results rather than raw experimental data.
• Data is derived solely from a mouse model, limiting direct applicability to human ulcerative colitis without further translational research.
• Specific row and column counts, data structure, and sample-level details are unknown from the provided description.

Provenance

Source

Figshare, authored by Yangyang Zhao.

Collection Method

Generated from a laboratory study using a DSS-induced ulcerative colitis mouse model treated with Daifu decoction, analyzed via multi-omics techniques and experimental verification.

Freshness

Last updated March 2026.