Oropouche Virus Virulence in AG129 Mice: Contemporary vs. Historical Strains

Experimental data compares virulence and neuroinvasion of contemporary Oropouche virus reassortant isolates against a historical prototype strain in the AG129 mouse model. The dataset likely contains measurements of viremia, viral loads across multiple organs, disease progression, mortality, and cytokine responses. It was authored by Ellen Caroline Nobre Santos and published on figshare in May 2026.

Use Cases

• Compare viral pathogenicity based on viremia and mortality data mentioned in the description
• Analyze viral dissemination patterns based on organ-specific viral load measurements
• Study host immune responses based on cytokine upregulation data
• Investigate the link between viral evolution and clinical severity based on experimental evidence

Strengths

• Data compares contemporary 2024 isolates with a historical prototype strain, providing a temporal contrast
• Experimental evidence covers multiple biological endpoints: viremia, organ loads, disease progression, and mortality
• Published under an open CC-BY-4.0 license

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is limited to a specific mouse model (AG129), which may not fully represent human infection

Provenance

Source

figshare

Collection Method

Experimental data from a mouse model study

Freshness

Last updated 2026-05-19 05:41:52; freshness should be verified

Geography

Includes isolates from Amazon Basin and non-Amazonian regions