E. coli UTI Model in Göttingen Minipigs with Strain Recovery Data

A 2026 study by Joyce Lübbers describes a novel urinary tract infection model using intraurethral challenge with UPEC strain UTI89 in Göttingen minipigs. The dataset includes results from bacterial enumeration, agglutination tests, and whole genome sequencing of recovered strains. It is a 37.5 KB document shared under a CC-BY-4.0 license.

Use Cases

• Evaluating vaccine efficacy based on the described intraurethral challenge model.
• Assessing antibiotic treatment outcomes using the bacterial enumeration data.
• Studying strain identity and contamination in animal models based on the agglutination and sequencing results.
• Bridging preclinical findings to human clinical outcomes as discussed in the study.

Strengths

• Includes specific results: 75% of animals infected with the challenge strain, 25% with a different E. coli strain.
• Describes a 14-day infection model, providing a defined experimental timeframe.
• Data provenance is clear, authored by a named researcher and published on figshare.

Limitations

• Dataset is a 37.5 KB DOCX file; the underlying structured data (e.g., columnar results) is not directly accessible.
• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The description is medium-completeness; specific numerical results beyond the stated percentages are not detailed.

Provenance

Source

figshare, author Joyce Lübbers.

Collection Method

Experimental study involving intraurethral bacterial challenge, urine collection, bacterial enumeration, agglutination testing, and whole genome sequencing.

Time Range

The study period is not specified, but the dataset was last updated in 2026.

Freshness

Last updated 2026-05-18 05:44:58.