Common Carp Cathepsin L Paralogs Expression and Infection Response

Nine cathepsin L paralogs in common carp reveal expression divergence across tissues and immune compartments. Sagar Nayak published this 90.6 KB dataset in April 2026, detailing transcriptional profiles during a Sphaerospora molnari infection.

Use Cases

• Analyze tissue-specific expression partitioning of ctsl.1A/B and ctslaA/B paralogs across mucosal barriers and systemic immune hubs.
• Model structural variation in protease loop architecture and active-site cleft geometry to predict divergent substrate preferences.
• Track temporal reprogramming of ctsl paralog expression profiles during myxozoan pathogen infection progression.
• Correlate inflammatory cytokine induction dynamics with transient ctsl downregulation in immune cells like head kidney leukocytes.

Strengths

• Identifies nine distinct cathepsin L paralogs retained from whole-genome duplication events.
• Includes expression data across multiple tissues and immune compartments, including blood and head kidney leukocytes.
• Provides temporal infection response data for the pathogen Sphaerospora molnari.

Limitations

• Dataset is small at 90.6 KB, indicating limited scope and likely a focused subset of experimental results.
• Row count and specific column names are unknown, limiting reproducibility and detailed analysis.
• Data is derived from a single species (common carp), limiting generalizability to other vertebrates.

Provenance

Source

figshare, authored by Sagar Nayak.

Collection Method

Experimental identification and analysis of gene paralogs, expression profiling, and infection modeling.

Time Range

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Freshness

Last updated April 2026.

Geography

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