Meta-Analysis Results on Febuxostat Effects for Renal Transplant Recipients

A meta-analysis of studies up to October 2024 on the effects of febuxostat in renal transplant recipients with hyperuricemia. The analysis includes quantitative results for uric acid levels, creatinine, estimated glomerular filtration rate, and other biochemical indices. The dataset, a 17.7 KB DOCX file, was authored by Sheng Chao and shared under a CC-BY-4.0 license on figshare.

Use Cases

• Validate the uric acid-lowering effect of febuxostat based on the reported mean difference of 129.981 μmol/L.
• Assess renoprotective claims by analyzing the reported changes in creatinine and estimated glomerular filtration rate.
• Explore correlations between febuxostat treatment and hemoglobin levels based on the reported significant increase.
• Conduct sensitivity analysis for meta-analytic findings based on the described robustness check.
• Identify gaps for future clinical studies based on the conclusion about uncertain renoprotective effects.

Strengths

• Includes specific quantitative results, such as a mean difference of 129.981 μmol/L for uric acid reduction.
• Reports statistical significance values (P-values) for multiple outcome measures.
• The meta-analysis protocol is registered with PROSPERO (CRD420261300034).
• Sensitivity analysis indicated that omitting most studies did not affect the findings.

Limitations

• The underlying data tables and column definitions are not provided, requiring inference from the summary.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a 17.7 KB DOCX file, indicating a very limited scope containing only summary results.

Provenance

Source

Sheng Chao via figshare.

Collection Method

Systematic review and meta-analysis of studies from Web of Science, PubMed, the Cochrane Library, Wan Fang, and CNKI.

Time Range

Literature search up to 17 October 2024.

Freshness

Last updated 2026-03-17 13:04:42; includes literature search up to 17 October 2024.

Geography

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