Serum Proteome Dose-Response in Healthy Dogs Following Cannabidiol Administration

A proteomics dataset comparing serum protein responses in 18 healthy dogs after 30 days of oral cannabidiol (CBD) administration via three distinct delivery matrices: hemp by-product feed pellets, CBD-infused oil, and a semi-solid treat. The data, published on figshare under a CC-BY-4.0 license, reveals formulation-specific proteomic signatures and a shared core metabolic response involving lipid metabolism and redox homeostasis. The dataset was last updated on 2026-05-13.

Use Cases

• Compare proteomic signatures based on different CBD delivery matrices (feed pellets, oil, treat).
• Investigate CBD-mediated modulation of lipid metabolism based on apolipoprotein expression changes.
• Analyze vascular integrity and tissue scaffolding protein expression in high-exposure groups.
• Study immunomodulatory and cytoprotective marker induction, such as clusterin (CLU), in specific formulation groups.

Strengths

• Includes data from 18 healthy dogs, providing a controlled cohort.
• Compares three distinct CBD delivery matrices over a 30-day administration period.
• Employs label-free quantitative proteomics, a standard method for protein quantification.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Dataset size is 10.2 KB, indicating a very limited scope of data.

Provenance

Source

figshare

Collection Method

Label-free quantitative proteomics analysis of canine serum.

Time Range

Study involved 30 days of CBD administration; specific collection dates unknown.

Freshness

Last updated 2026-05-13 05:56:06; freshness should be verified.