Table 5: Clinical and Molecular Associations for Phthalate-Linked Diabetic Retinopathy

A 21.2 KB document presents results from an integrative analysis of diabetic retinopathy risk factors. The study analyzed data from the 2017–2018 NHANES survey and an independent clinical cohort, identifying associations with outdoor time, vitamin D levels, and phthalate exposure. It was authored by Zhiwei Xu and last updated on 2026-05-13.

Use Cases

• Identify novel clinical risk factors for diabetic retinopathy based on NHANES and clinical cohort data.
• Explore associations between environmental phthalate exposure and diabetic retinopathy pathogenesis.
• Investigate molecular mechanisms via network toxicology and docking analyses targeting pathways like AGE-RAGE signaling.
• Validate predicted binding interactions of phthalate metabolites with proteins like SRC, BCL2, and MAPK1.

Strengths

• Integrates data from two distinct sources: the nationally representative 2017–2018 NHANES and an independent clinical cohort.
• Employs multiple analytical methods, including feature selection, network toxicology, and molecular docking.
• Reports specific odds ratios, such as 3.18 for weekday outdoor time and 11.0 for cataract association.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 21.2 KB, indicating limited scope, likely containing summary results rather than raw data.

Provenance

Source

Analysis of the 2017–2018 National Health and Nutrition Examination Survey (NHANES) and an independent clinical cohort.

Collection Method

Multiple feature-selection methods, network toxicology, and molecular docking analyses.

Time Range

Primary survey data from 2017–2018.

Freshness

Last updated 2026-05-13 04:39:38; freshness should be verified.

Geography

United States (NHANES) and an unspecified location for the clinical cohort.