GLIS3 Expression and Clinical Data for Stomach Adenocarcinoma

Qi Xiao published a dataset on figshare in 2026 investigating the role of GLIS3 in stomach adenocarcinoma. The data includes GLIS3 expression levels from public transcriptomic datasets and a clinical cohort of 133 paired STAD tissues, along with associated survival and clinicopathological features. The study also includes results from functional and mechanistic experiments in cell lines and xenograft models.

Use Cases

• Assessing the prognostic value of GLIS3 expression for patient survival based on Kaplan-Meier and multivariable regression analyses.
• Investigating the association between GLIS3 expression and clinicopathological features like nodal burden and metastatic status.
• Studying the GLIS3-TGFBR3-Hedgehog signaling axis and its role in promoting EMT and CSC-like traits based on functional assays.
• Validating GLIS3 as a potential biomarker for risk stratification in stomach adenocarcinoma.

Strengths

• Includes data from a clinical cohort of 133 paired STAD tissues with immunohistochemistry protein level evaluation.
• Integrates transcriptomic data from multiple public sources: The Cancer Genome Atlas, Genotype-Tissue Expression, and Gene Expression Omnibus.
• Provides hazard ratios and confidence intervals from multivariable Cox models for survival analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 16.5 KB, indicating limited scope, likely containing summary results rather than raw experimental data.

Provenance

Source

figshare, author Qi Xiao

Collection Method

Analysis of public transcriptomic datasets and a proprietary clinical tissue cohort, combined with in vitro and in vivo functional studies.

Freshness

Last updated 2026-05-21 04:19:28; freshness should be verified.