Common Genes Associated with Diabetic Nephropathy and Retinopathy

A bioinformatics study identified 206 common genes from transcriptome data GSE185011, intersecting 526 DN-related and 1,059 DR-related differentially expressed genes. The analysis, uploaded by Juan He on April 28, 2026, screened 6 diagnostic genes for diabetic nephropathy and 4 for diabetic retinopathy, and constructed TF-mRNA-miRNA regulatory networks.

Use Cases

• Identify potential diagnostic biomarkers for diabetic nephropathy based on the 6 identified genes (METTL27, NMNAT2, TTC25, GAS6, ATP4A, ZNF223).
• Investigate shared molecular pathways between diabetic nephropathy and retinopathy based on the 206 common genes.
• Analyze immune cell infiltration differences in diabetic complications based on the described changes in central memory CD4 T cells and activated B cells.
• Study transcriptional regulation in diabetic complications using the constructed TF-mRNA-miRNA networks (e.g., involving EGR1 and hsa-mir-101-3p).

Strengths

• Identifies specific diagnostic gene counts: 6 for diabetic nephropathy and 4 for diabetic retinopathy.
• Reports concrete intersection results: 206 common genes derived from 526 and 1,059 differentially expressed gene sets.
• Includes detailed methodological steps for gene screening and network analysis as described.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 9.3 KB, indicating limited scope.

Provenance

Source

Transcriptome data GSE185011 from figshare.

Collection Method

Bioinformatics analysis using limma for DEG screening, LASSO for diagnostic gene selection, and Metascape/ClusterProfiler for enrichment.

Freshness

Last updated 2026-04-28 05:24:47; freshness should be verified.