TP53 H179 Mutation Analysis in NSCLC: Structural Characterization from Molecular Dynamics

A research document analyzing TP53 gene mutations at the His179 locus in Non-Small Cell Lung Cancer (NSCLC) subtypes. The study evaluated mutational profiles from 616 lung adenocarcinoma (LUAD) and 544 lung squamous cell carcinoma (LUSC) individuals from TCGA, using molecular dynamics simulations to assess structural and functional ramifications. The document was authored by Ankur Datta and last updated on 2026-04-10.

Use Cases

• Study the prevalence of TP53 H179 mutations based on the analysis of 1,160 LUAD and LUSC cases from TCGA
• Analyze structural perturbations in p53 protein loops based on molecular dynamics simulation results described
• Compare zinc-binding affinity changes across H179 variants (Y/R/N/L/D) based on the binding affinity evaluations mentioned
• Investigate mutation-induced conformational signatures and protein stability based on the described energy landscape and contact map analyses

Strengths

• Focuses on a specific, underexplored structural site (His179) within a critical cancer gene (TP53)
• Analysis is based on a defined cohort of 1,160 NSCLC patients from TCGA
• Employs a multi-method approach combining mutational profiling, structural analysis, and molecular dynamics simulations

Limitations

• The dataset is a 13.1 KB DOCX file, indicating a very limited scope, likely a summary document rather than raw data
• Column-level documentation and sample data are unavailable, preventing assessment of data structure
• Row count is unknown, which may limit suitability assessment for computational analysis

Provenance

Source

figshare, author Ankur Datta

Collection Method

Analysis of TCGA mutational profiles and subsequent molecular dynamics simulations

Time Range

Temporal coverage of the underlying TCGA data is not specified

Freshness

Last updated 2026-04-10 05:59:26

Geography

Spatial coverage is not specified