Table 5_Integrated transcriptomic profiling of programmed cell death patterns unveils macr

A 19.2 KB dataset containing integrated bulk and single-cell transcriptomic analysis results for hepatic ischemia-reperfusion injury (HIRI). The data, authored by Manling Xie and last updated in May 2026, identifies 25 differentially expressed programmed cell death-related genes and 5 hub genes (THBS1, MAP1LC3B, PPP1R15A, CXCL8, ZC3H12A) used in a risk prediction model.

Use Cases

• Validate the THBS1-CD47 axis mechanism in macrophage-hepatocyte crosstalk based on the described transcriptomic profiles.
• Build risk prediction models for hepatic ischemia-reperfusion injury based on the 5 identified hub genes.
• Analyze heterogeneity in programmed cell death patterns (e.g., anoikis, pyroptosis) within the HIRI microenvironment as described in the single-cell analysis.
• Investigate the suppression of the PI3K-AKT-NF-κB signaling pathway using the described gene expression data from in vitro co-culture experiments.

Strengths

• Integrated analysis combines bulk transcriptomic data from 4 GEO datasets (GSE151648, GSE14951, GSE12720, GSE171539) with single-cell transcriptomic validation.
• Identifies 25 consistently upregulated programmed cell death-related genes and 5 hub genes used for risk stratification.
• Results are validated through in vivo animal models and in vitro co-culture experiments as described.

Limitations

• Row count and column-level documentation are unknown; field semantics must be inferred after download.
• The dataset is very small (19.2 KB), indicating it likely contains summary results or a single table rather than raw expression data.
• Description metadata is limited; actual data structure and quality require manual inspection of the DOCX file.

Provenance

Source

Gene Expression Omnibus (GEO) databases GSE151648, GSE14951, GSE12720, and GSE171539, with additional experimental validation.

Collection Method

Bulk and single-cell transcriptomic analysis, machine learning algorithms for feature selection, and in vivo/in vitro experimental validation.

Freshness

Last updated 2026-05-19 04:22:43; freshness should be verified.