Integrated Single-Cell and Bulk RNA-Seq Data for SF-1 Lineage PitNETs

Changxi Han published integrated single-cell and bulk RNA sequencing data from Steroidogenic Factor-1 (SF-1) lineage Pituitary Neuroendocrine Tumors (PitNETs) on figshare in April 2026. The 1.8 MB dataset under a CC-BY-4.0 license was used to identify a proliferative tumor subgroup driven by RGS4 expression. The analysis links RGS4 to p53 destabilization and tumor cell proliferation.

Use Cases

• Identify molecular subgroups within SF-1 lineage PitNETs based on integrated scRNA-seq and bulk RNA-seq data mentioned in the description
• Validate RGS4 as a functional driver gene for tumor proliferation using the provided transcriptomic profiles
• Investigate the RGS4-p53 axis as a potential therapeutic target in pituitary adenomas

Strengths

• Dataset integrates both single-cell and bulk RNA sequencing data, a multi-modal approach for tumor analysis
• Functional validation of the top candidate gene RGS4 is described, linking the data to mechanistic insights

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment for large-scale modeling

Provenance

Source

figshare

Collection Method

Integrated analysis of scRNA-seq and bulk transcriptomic datasets from SF-1 lineage PitNETs.

Freshness

Last updated 2026-04-22 05:49:44