Table 5_LRP1 as a potential diagnostic and immunomodulatory target in endometriosis: evide

1,404 differentially expressed genes were identified from three merged GEO datasets (GSE7305, GSE11691, GSE25628) to study endometriosis pathogenesis. The dataset, authored by Chengmao Xie and last updated in April 2026, presents findings on the role of low-density lipoprotein receptor-related protein 1 (LRP1) as a diagnostic and immunomodulatory target. It includes results from machine learning, immune profiling, Mendelian randomization, and single-cell RNA sequencing analyses.

Use Cases

• Validate a diagnostic model for endometriosis based on the 30 identified hub genes.
• Investigate the correlation between LRP1 expression and M2 macrophage infiltration in endometriosis tissue.
• Study cell-cell communication pathways, such as the MIF signaling pathway and CD74/CXCR4 interactions, using single-cell data.
• Assess the causal relationship between LRP1 and endometriosis risk through Mendelian randomization analysis results.

Strengths

• Integrates data from three public GEO datasets (GSE7305, GSE11691, GSE25628), providing a multi-source foundation.
• Includes validation from multiple analytical methods: machine learning (30 hub genes), immune profiling (r=0.62 correlation), Mendelian randomization (OR=1.35), and single-cell RNA sequencing.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and sharing.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small (19.4 KB), suggesting it contains summary or processed results rather than raw sequencing data.
• Geographic and demographic sources for the underlying GEO data are not specified, which may limit bias assessment.

Provenance

Source

figshare, author Chengmao Xie

Collection Method

Integrated analysis of public Gene Expression Omnibus (GEO) datasets using WGCNA, machine learning, and single-cell RNA sequencing.

Time Range

Temporal coverage of the underlying GEO datasets is not specified.

Freshness

Last updated 2026-04-15 04:22:12; freshness should be verified.

Geography

Spatial coverage is not specified.