Macrolide Resistance Trajectories in Bordetella Pertussis Under Erythromycin Exposure

Experimental data tracks the evolution of macrolide resistance in three clinical Bordetella pertussis isolates under stepwise erythromycin exposure. The dataset includes phenotypic readouts such as antimicrobial susceptibility testing, growth and biofilm assays, and ELISA-based measurements of virulence- and metabolism-associated factors. It was authored by Kaichong Jiang and last updated on 2026-04-17.

Use Cases

• Modeling antibiotic resistance trajectories based on genetic background and phenotypic readouts.
• Analyzing correlations between genomic alterations and phenotypic changes like growth and biofilm formation.
• Comparing resistance mechanisms (e.g., 23S rRNA mutations vs. efflux-associated variants) across different bacterial lineages.

Strengths

• Data includes whole-genome sequencing results for tracking resistance-associated variants.
• Phenotypic readouts cover multiple assays: antimicrobial susceptibility, growth, biofilm, and ELISA measurements.
• Focuses on three distinct, clinically relevant genetic backgrounds for comparative analysis.

Limitations

• Row count and specific column definitions are unknown, limiting suitability assessment.
• The dataset is small (12.4 KB), indicating a limited experimental scope.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare, author Kaichong Jiang.

Collection Method

Stepwise erythromycin induction experiments on three clinical isolates, with tracking via whole-genome sequencing and phenotypic assays.

Freshness

Last updated 2026-04-17 05:20:57.