MicroRNA Expression in Canine Visceral Hemangiosarcoma FFPE Tissues

Laura Machado Ribas published this dataset on figshare in March 2026. It contains differential expression analysis results for microRNAs in formalin-fixed, paraffin-embedded tissues from 24 dogs with visceral hemangiosarcoma and 12 non-neoplastic controls. The analysis identified 67 and 71 differentially expressed miRNAs in splenic and cardiac tumors, respectively, with 18 shared between types.

Use Cases

• Identifying potential diagnostic miRNA biomarkers for canine visceral hemangiosarcoma based on the validated differentially expressed miRNAs.
• Analyzing oncogenic pathway involvement (e.g., PI3K-Akt, MAPK) based on the pathway enrichment results described.
• Comparing miRNA expression profiles between splenic and cardiac tumor subtypes based on the shared and unique miRNAs identified.
• Assessing the utility of archived FFPE tissues for biomarker discovery as highlighted in the study discussion.

Strengths

• Data is derived from a study analyzing 36 samples (24 tumor, 12 control).
• Results include validation by RT-qPCR for 13 differentially expressed miRNAs in each tissue type.
• Pathway enrichment analysis links findings to specific oncogenic signaling pathways.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 11.7 KB, indicating limited scope.

Provenance

Source

Laura Machado Ribas via figshare.

Collection Method

Analysis of FFPE tissues using small RNA sequencing and quantitative PCR.

Time Range

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Freshness

Last updated 2026-03-17 14:39:58; freshness should be verified.

Geography

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