Mouse Lung Proteome Data for Millettia Speciosa Asthma Treatment Study

Hangrui Yang published proteomic data on figshare in June 2026. The dataset contains results from a study investigating the therapeutic effects of Niudali (Millettia speciosa) in an ovalbumin-induced mouse model of allergic asthma. It includes analysis of 179 differentially expressed proteins and cytokine profiles from bronchoalveolar lavage fluid.

Use Cases

• Identify protein biomarkers for asthma treatment response based on the 179 differentially expressed proteins.
• Study the inhibition of the CCL24-eosinophil axis as a therapeutic mechanism for allergic inflammation.
• Analyze immunometabolic pathway modulation, such as PPAR signaling and complement cascades, from proteomic enrichment results.
• Investigate the role of hub proteins like Alb, Apoe, and Apoa1 in immune regulation and lipid metabolism within lung tissue.

Strengths

• Includes analysis of 179 differentially expressed proteins identified via high-resolution data-independent acquisition proteomics.
• Findings are integrated with cytokine profiling data showing reductions in IgE, IL-4, IL-5, and IL-6.
• Dataset is openly licensed under CC-BY-4.0, permitting reuse with attribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The study's proposed link to the gut-lung axis is noted as hypothetical and not directly investigated.

Provenance

Source

Hangrui Yang via figshare.

Collection Method

High-resolution data-independent acquisition (DIA) lung proteomics integrated with cytokine profiling from an ovalbumin-induced mouse model.

Freshness

Last updated 2026-06-03 07:42:24; freshness should be verified.