Neuro-Ophthalmic Complications of Tuberculosis: Systematic Review and Meta-Analysis

Twenty-two studies (N=260,430) were included in this systematic review and meta-analysis published by Ahmed A. Alessa in 2026. The pooled incidence of ethambutol optic neuropathy was 1.54%, with renal impairment and hypertension identified as significant risk factors. The review also reports neuro-ophthalmic manifestations of tuberculous meningitis and compares biomarker efficacy.

Use Cases

• Estimate the incidence of ethambutol optic neuropathy based on the pooled 1.54% rate.
• Identify risk factors for neuro-ophthalmic complications based on reported odds ratios for renal impairment and hypertension.
• Compare diagnostic biomarker efficacy based on the Hedges' g difference reported for visual evoked potential versus optical coherence tomography.
• Analyze visual recovery outcomes based on the 52.4% recovery rate and associated factors like age and treatment timing.

Strengths

• Analysis includes 260,430 participants from 22 studies.
• Provides specific pooled incidence rates (e.g., 1.54% for EON) and risk factor odds ratios (e.g., OR 3.73 for renal impairment).
• Follows PRISMA 2020 guidelines and is registered with PROSPERO (CRD420251141453).

Limitations

• The dataset is a 17.7 KB document; the underlying structured data tables are not provided.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Ahmed A. Alessa

Collection Method

Systematic review and meta-analysis of studies from PubMed, Scopus, Embase, Web of Science, Cochrane Library, and Google Scholar.

Time Range

Studies searched up to September 30, 2025.

Freshness

Last updated 2026-05-29 04:44:47; freshness should be verified.