Peripheral CD4+ Naïve T Cell and MMP1 Signatures in Acute Gouty Arthritis

Chinese and European ancestry cohorts were used to investigate immune remodeling in acute gouty arthritis. The dataset likely contains results from Mendelian randomization, mass cytometry (CyTOF), single-cell RNA-seq re-analysis, and plasma proteomic analyses. It was authored by Peng Zhang and last updated on 2026-05-26.

Use Cases

• Identify genetic associations between immune cell phenotypes and gout risk based on Mendelian randomization results.
• Characterize peripheral immune cell expansion and remodeling during acute flares based on CyTOF and single-cell RNA-seq analyses.
• Evaluate plasma protein biomarkers like MMP1 and S100A12 for acute flare association and recurrence risk stratification.
• Investigate cell-cell communication signaling pathways such as MIF–CXCR2 and ANXA1–FPR1 in gout inflammation.

Strengths

• Integrates multiple analysis methods: bidirectional Mendelian randomization, CyTOF, single-cell RNA-seq, and plasma proteomics.
• Includes data from specific cohort sizes: CyTOF analysis used samples from 25 GA-A, 22 GA-R, and 9 healthy control patients.
• Reports specific exploratory findings, such as an AUC of 0.8533 for MMP1 in 12-week recurrence risk stratification within a subgroup.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small at 13.3 KB, indicating limited scope, likely containing summary results rather than raw data.
• Data may reflect geographic bias inherent to the specific Chinese and European ancestry cohorts studied.

Provenance

Source

figshare, authored by Peng Zhang.

Collection Method

Integrated analysis using publicly available GWAS datasets, CyTOF of PBMC samples, re-analysis of public single-cell RNA-seq data, and plasma proteomics via the Olink platform.

Freshness

Last updated 2026-05-26 06:03:51; freshness should be verified.

Geography

Studies include European ancestry GWAS data and Chinese patient cohorts.