Placental Transcriptome Profiles for Congenital Chagas Disease Transmission Analysis

A transcriptomic analysis of placental tissues from deliveries of congenitally infected, exposed but uninfected, and unexposed/uninfected newborns. The dataset, authored by Sofia Apodaca and last updated on 2026-03-18, contains differential gene expression results from RNA-seq data. It identifies key placental transcriptional alterations associated with congenital Trypanosoma cruzi transmission.

Use Cases

• Identify differentially expressed genes associated with congenital transmission based on comparisons between infected and uninfected placental groups.
• Perform gene set enrichment analysis based on the described alterations in immune-related and extracellular matrix-related pathways.
• Investigate the role of specific genes like CEMIP, PRRX1, and CADM3 in placental cell adhesion and structural integrity.
• Validate co-expression network models using the identified hub genes ENPP1 and SLC16A10.

Strengths

• Data is derived from a transcriptomic (RNA-seq) analysis, which provides a high-resolution molecular profile.
• Analysis includes comparisons across three distinct clinical groups (M+B+, M+B−, M−B−) to isolate transmission factors.
• Findings are supported by multiple analytical methods including differential expression, gene set enrichment, and co-expression network analysis.

Limitations

• The dataset is very small at 45.7 KB, suggesting it likely contains summary results rather than raw sequencing data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale modeling.

Provenance

Source

Sofia Apodaca via figshare

Collection Method

RNA-seq transcriptomic analysis of placental tissues from defined clinical groups.

Freshness

Last updated 2026-03-18 06:43:03