Plasma Proteome Mendelian Randomization for Gastric Cancer Drug Targets Across Ancestries

Peng Zhi's dataset contains results from a Mendelian randomization study identifying ancestry-specific plasma protein targets for gastric cancer. The analysis revealed 13 protein targets, including four significant in European and nine in East Asian populations. The dataset was last updated on 2026-05-01 and is shared under a CC-BY-4.0 license.

Use Cases

• Identify potential drug targets for gastric cancer based on ancestry-specific plasma protein associations.
• Prioritize proteins for experimental validation based on Mendelian randomization and colocalization results.
• Explore cross-ancestry therapeutic potential of drugs like digoxin through molecular docking findings.
• Investigate cellular expression patterns of identified targets in epithelial and pit mucous cells from gastric tumor tissue.

Strengths

• Identifies 13 specific protein targets, including five novel candidates, for gastric cancer.
• Provides ancestry-specific analysis, distinguishing between European and East Asian populations.
• Includes experimental validation results for NME4 and ICAM5 in cell lines and tissue samples.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small at 10.0 KB, indicating limited scope, likely containing summary results rather than raw data.
• Last updated 2026-05-01; freshness should be verified as it is a future date.

Provenance

Source

Peng Zhi via figshare

Collection Method

Mendelian randomization and colocalization analysis of plasma proteome data, supplemented by single-cell RNA sequencing and molecular docking.

Freshness

Last updated 2026-05-01 04:19:30

Geography

Populations of European and East Asian ancestry